En m’appuyant sur une distinction de Daniel Laurier entre holismes métaphysique et épistémique ainsi que sur le fait généralement admis qu’il n’y a que deux types de relations susceptibles de prévaloir entre états mentaux, j’évalue différentes définitions, proposées par Donald Davidson, de l’attitude de tenir une phrase pour vraie, soient celle qui fait de cette attitude une attitude propositionnelle, celle qui prétend qu’elle est une attitude non individuative et, enfin, celle qui suggère qu’elle est une action. J’essaie de voir les (...) conséquences qu’entraîne, sur le plan des relations entre états mentaux, l’inclusion de cette attitude, selon les définitions analysées, dans le holisme psycholinguistique, lequel est un holisme métaphysique et concerne les phrases de la langue d’un locuteur ainsi que ses croyances. Je termine en suggérant que la voie la plus prometteuse concernant cette attitude est de la définir comme une attitude non individuative, qu’il faut prendre soin de distinguer des autres états mentaux à contenu non propositionnel, comme les états expérientiels.Relying on a distinction conceived of by Daniel Laurier between metaphysical and epistemic holism as well as the generally accepted fact that there are only two types of relations thought to prevail between mental states, I will evaluate different definitions, proposed by Donald Davidson, of the attitude of holding a sentence true: one that construes it as a propositional attitude, one claiming that it is a nonindividuative attitude, and finally one suggesting that it is an action. I examine the consequences that follow from an inclusion of this attitude, at the level of relations between mental states and as a result of the various definitions, into psycholinguistic holism. Psycholinguistic holism is a type of metaphysical holism that is concerned with the sentences of a speaker’s language as well as his beliefs. I end by suggesting that the most promising path to take with regard to this attitude is to define it as a nonindividuative attitude, that one must be careful to distinguish it from the other mental states with non-propositional content, such as experience states. (shrink)

IntroductionThe prefrontal cortex plays a crucial role in cognition, particularly in executive functions. Cortical reactivity measured with Transcranial Magnetic Stimulation combined with Electroencephalography is altered in pathological conditions, and it may also be a marker of cognitive status in middle-aged adults. In this study, we investigated the associations between cognitive measures and TMS evoked EEG reactivity and explored whether the effects of this relationship were related to neurofilament light chain levels, a marker of neuroaxonal damage.MethodsFifty two healthy middle-aged adults from (...) the Barcelona Brain Health Initiative cohort underwent TMS-EEG, a comprehensive neuropsychological assessment, and a blood test for NfL levels. Global and Local Mean-Field Power, two measures of cortical reactivity, were quantified after left prefrontal cortex stimulation, and cognition was set as the outcome of the regression analysis. The left inferior parietal lobe was used as a control stimulation condition.ResultsLocal reactivity was significantly associated with working memory and reasoning only after L-PFC stimulation. No associations were found between NfL and cognition. These specific associations were independent of the status of neuroaxonal damage indexed by the NfL biomarker and remained after adjusting for age, biological sex, and education.ConclusionOur results demonstrate that TMS evoked EEG reactivity at the L-PFC, but not the L-IPL, is related to the cognitive status of middle-aged individuals and independent of NfL levels, and may become a valuable biomarker of frontal lobe-associated cognitive function. (shrink)

In recent years, supported by new scientific evidence, the conceptualization of cognitive reserve has been progressively enriched and now encompasses not only cognitive stimulating activities or educational level, but also lifestyle activities, such as leisure physical activity and socialization. In this context, there is increasing interest in understanding the role of psychological factors in brain health and cognitive functioning. In a previous study, we have found that these factors mediated the relationship between CR and self-reported cognitive functioning. In this study, (...) we have confirmed an association between two important constructs included in the psychological wellbeing and salutogenic models, “purpose in life” and “sense of coherence,” CR, as assessed using a questionnaire, and cognitive functioning, as evaluated using a comprehensive neuropsychological battery. Results from 888 middle-aged healthy participants from the Barcelona Brain Health Initiative indicate that both sense of coherence and CR were positively associated with verbal memory, reasoning and attention, working memory, and global cognition. Moreover, the relation between CR and cognitive functioning in the different domains is partially mediated by SoC. When we controlled for brain integrity, introducing into the model neurofilament light chain measures, the mediator role of SoC was confirmed for reasoning and attention and global cognition. However, purpose in life was not associated with cognitive functioning. These results reveal the central role of the SoC construct, which mediates the association between classic CR estimates and cognitive functions, potentially representing a modifiable target for interventions that aim to promote brain health. (shrink)

IntroductionExcitability of the primary motor cortex measured with TMS has been associated with cognitive dysfunctions in patient populations. However, only a few studies have explored this relationship in healthy adults, and even fewer have considered the role of biological sex.MethodsNinety-seven healthy middle-aged adults completed a TMS protocol and a neuropsychological assessment. Resting Motor Threshold and Long-Interval Intracortical Inhibition were assessed in the left motor cortex and related to attention, episodic memory, working memory, reasoning, and global cognition composite scores to evaluate (...) the relationship between cortical excitability and cognitive functioning.ResultsIn the whole sample, there was a significant association between LICI and cognition; specifically, higher motor inhibition was related to better working memory performance. When the sample was broken down by biological sex, LICI was only associated with working memory, reasoning, and global cognition in men. No associations were found between RMT and cognitive functions.ConclusionGreater intracortical inhibition, measured by LICI, could be a possible marker of working memory in healthy middle-aged adults, and biological sex plays a critical role in this association. (shrink)

Objective: Loneliness is the subjective distress of feeling alone and has a strong impact on wellbeing and health. In addition to well-known predictors like isolation and poor health, a better understanding of the psychological determinants of loneliness would offer effective targets for future complementary interventions.Methods: In this cross-sectional observational study, we compared the explanatory power of several important risk factors of loneliness with the affective, motivational, and cognitive aspects of the Meaning in Life construct. Different nested linear models were compared (...) including socio-demographic, lifestyles, social-connectedness, and self-rated health variables, to assess the overlapping and non-overlapping explanatory power of each of them.Results: Health status and MiL were found to be the most important predictors of loneliness, followed by social connectedness and, with a much lower weight, lifestyles, and socio-demographic factors. Within the MiL factor, the most cognitive component, sense of coherence, had a greater explanatory power than the more affective and motivational ones.Conclusion: Reduced MiL, the capacity of an individual to attach “value and significance” to life, is a crucial predictor to the feeling of loneliness. These results suggest that programs aiming to combat loneliness should go well beyond situational interventions and include more cognitive, value-centered interventions that enable individuals to define and pursue a meaningful vital plan. (shrink)

This text provides an account of dissonance theory and reduction. It studies the evolution of cognitive dissonance theory, providing a review and a new interpretation of Festinger's original theory - the "radical conception". The authors present research arising from this new interpretation, adding to Festinger's theory by emphasizing the importance of the status of behaviour. Their research and evidence is intended to strengthen and clarify Festinger's original and innovative arguments.

The new paradigm in the psychology of reasoning adopts a Bayesian, or prob- abilistic, model for studying human reasoning. Contrary to the traditional binary approach based on truth functional logic, with its binary values of truth and falsity, a third value that represents uncertainty can be introduced in the new paradigm. A variety of three-valued truth table systems are available in the formal literature, including one proposed by de Finetti. We examine the descriptive adequacy of these systems for natural language (...) indicative condi- tionals and bets on conditionals. Within our framework the so-called “defective” truth table, in which participants choose a third value when the antecedent of the indicative conditional is false, becomes a coherent response. We show that only de Finetti’s system has a good descriptive fit when uncer- tainty is the third value. (shrink)

À travers une série d’entretiens avec une quarantaine de joueurs intensifs de jeux en ligne massivement multijoueurs , nous analysons pourquoi World of Warcraft est si attractif. On peut formuler l’hypothèse que cela tient à la structure même du jeu, à la fascination et au plaisir que celui-ci procure et aux importants intérêts commerciaux qu’en retirent les entreprises exploitantes.Through a series of interviews with about forty game players devoting more than fifteen hours a week to MMO , we analyse the (...) reasons for the attraction exerted by World of Warcraft. We put forward the hypothesis that the attraction stems from the structure of the game itself, the fascination and pleasure derived from it and the substantial commercial benefits for the companies operating the game. (shrink)

La révolution peut-elle être gazouillée ? Peut-on parler d’une révolution 2.0 dans le cas de l’utilisation de Twitter et des réseaux sociaux numériques pendant la révolte des populations arabes dans la première moitié de 2011 ? Faut-il plutôt analyser le rôle et l’importance des outils de communication dans le processus de réveil des populations longtemps maintenues au silence par des régimes autoritaires?Does the use of Twitter and social networks sites during the Arab revolts in early 2011 amount to a revolution (...) 2.0? Or would it be more relevant to analyse the role and importance of communication tools generally in the awakening of populations silenced for so many years by authoritarian regimes? (shrink)

Psychological research on people’s understanding of natural language connectives has traditionally used truth table tasks, in which participants evaluate the truth or falsity of a compound sentence given the truth or falsity of its components in the framework of propositional logic. One perplexing result concerned the indicative conditional if A then C which was often evaluated as true when A and C are true, false when A is true and C is false but irrelevant“ (devoid of value) when A is (...) false (whatever the value of C). This was called the “psychological defective table of the conditional.” Here we show that far from being anomalous the “defective” table pattern reveals a coherent semantics for the basic connectives of natural language in a trivalent framework. This was done by establishing participants’ truth tables for negation, conjunction, disjunction, conditional, and biconditional, when they were presented with statements that could be certainly true, certainly false, or neither. We review systems of three-valued tables from logic, linguistics, foundations of quantum mechanics, philosophical logic, and artificial intelligence, to see whether one of these systems adequately describes people’s interpretations of natural language connectives. We find that de Finetti’s (1936/1995) three-valued system is the best approximation to participants’ truth tables. (shrink)

This paper is not an article in a regular sense. It is a dialogue between François-David Sebbah, one of the two editors of this topical collection, and Jean-Luc Nancy, one of the most eminent representatives of the contemporary French Thought. This dialogue took place in the first half of 2022 in a written form, because of the sanitary restrictions related to the COVID-19 pandemic and because Nancy was heavily sick. Sebbah sent to Nancy a text, corresponding to Section (...) 2.1, and Nancy responded to it with another text, corresponding to Section 2.2. Unfortunately, Nancy died on August 23, 2022, and could not revise his own text nor pursue the dialogue, as it was originally planned. For this reason, an introductory clarification by Sebbah, corresponding to Section 1, has been added. The purpose of such clarification is to introduce the reader to Nancy’s philosophy of technology—although technology never had a central role in Nancy’s reflections. In Section 2.1, Sebbah proposes a distinction between “French Theory,” “French Thought,” and “French Philosophy.” He also proposes a list of twelve possible intersections between the French Thought and the philosophy of technology. In Section 2.2, Nancy criticizes the use of expressions such as “French Thought.” He also insists, in a Heideggerian vein, on the fact that Technology (with a capital “T”) does not depend on human ends but has its own ends. (shrink)

The dynamics of the "Etang de Berre", a brackish lagoon situated close to the French Mediterranean sea coast, is strongly disturbed by freshwater inputs coming from an hydroelectric power station. The system dynamics has been described as a sequence of daily typical states from a set of physicochemical variables such as temperature, salinity and dissolved oxygen rates collected over three years by an automatic sampling station. Each daily pattern summarizes the evolution, hour by hour of the physicochemical variables. This article (...) presents results of forecasts of the states of the system subjected to the simultaneous effects of meteorological conditions and freshwater releases. We recall the main step of the classification tree method used to build up the predictive model (Classification and Regression Trees, Breiman et al., 1984) and we propose a transfer procedure in order to test the stability of the model. Results obtained on the Etang de Berre data set allow us to describe and predict the effects of the environmental variables on the system dynamics with a margin of error. The transfer procedure applied after the tree building process gives a maximum gain in prediction accuracy of about 15%. (shrink)

Worldwide populations are aging with economic development as a result of public health initiatives and advances in therapeutic discoveries. Since 1850, life expectancy has advanced by 1 year for every four. Accompanying this change is the rapid development of anti‐aging science. There are three schools of thought in the field of aging science. One perspective is the life course approach, which considers that aging is a good and natural process to be embraced as a necessary and positive aspect of life, (...) where the aim is to improve the quality of existing lifespan and “compress” morbidity. Another view is that aging is undesirable, and that rejuvenation and indeed immortality are possible since the biological basis of aging is understood, and therefore, strategies are possible for engineering negligible senescence. Finally, a hybrid approach is that life span can be extended by anti‐aging medicines but with uncertain effects on health. While these advances offer much promise, the ethical perspectives are seldom discussed in cross‐disciplinary settings. This article discusses some of the key ethical issues arising from recent advances in biogerontology. (shrink)

First translated into English in 1991, God Without Being continues to be a key book for discussions of the nature of God. This second edition contains a new preface by Marion as well as his 2003 essay on Thomas Aquinas.

In absence of effective pharmaceutical treatments, the individual's compliance with a series of behavioral recommendations provided by the public health authorities play a critical role in the control and prevention of SARS-CoV2 infection. However, we still do not know much about the rate and determinants of adoption of the recommended health behaviors. This paper examines the compliance with the main behavioral recommendations, and compares sociocultural, psychosocial, and social cognitive explanations for its variation in the French population. Based on the current (...) literature, these 3 categories of factors were identified as potential determinants of individual differences in the health preventive behaviors. The data used for these analyses are drawn from 2 cross-sectional studies conducted after the lockdown and before the peak of the COVID-19 epidemic in France. The participants were drawn from a larger internet consumer panel where recruitment was stratified to generate a socio-demographically representative sample of the French adult population. Overall, the results show a very high rate of compliance with the behavioral recommendations among the participants. A hierarchical regression analysis was then performed to assess the potential explanatory power of these approaches in complying with these recommendations by successively entering sociocultural factors, psychosocial factors, social cognitive factors in the model. Only the inclusion of the cognitive variables substantially increased the explained variance of the self-reported adoption of preventive behaviors, providing better support for the social cognitive than the sociocultural and psychosocial explanations. (shrink)

ABSTRACT The article reports on a survey of English primary school head teachers? opinions on disruptive behaviour, coupled with a one?day exercise in the monitoring of disruptive incidents in the same schools. Eighty?five highly experienced head teachers from 38 local education authorities responded to an extensive questionnaire and 77 schools monitored incidents. Schools were categorised by the LEAs as potentially ?difficult?, ?of average difficulty? and ?easy? in respect of intake. Thirty?six Principal Educational Psychologists contributed briefly on a question on age (...) of onset. Findings relate to (a) an examination of the question whether the age of onset of disruptive behaviour is getting earlier, (b) the differing perceptions of questions concerning disruptive behaviour of head teachers, in schools of varying potential difficulty of intake, and (c) the coping strategies used and favoured by head teachers in their work with disruptive behaviour. (shrink)

The hypothesis that the particular linear tracks appearing in the measurement of a spherically-emitting radioactive source in a cloud chamber are determined by the positions of atoms or molecules inside the chamber is further explored in the framework of a recently established one-dimensional model. In this model, meshes of localized spins 1/2 play the role of the cloud-chamber atoms and the spherical wave is replaced by a linear superposition of two wave packets moving from the origin to the left and (...) to the right, evolving deterministically according to the Schrödinger equation. We first revisit these results using a time-dependent approach, where the wave packets impinge on a symmetric two-sided detector. We discuss the evolution of the wave function in the configuration space and stress the interest of a non-symmetric detector in a quantum-measurement perspective. Next we use a time-independent approach to study the scattering of a plane wave on a single-sided detector. Preliminary results are obtained, analytically for the single-spin case and numerically for up to 8 spins. They show that the spin-excitation probabilities are sometimes very sensitive to the parameters of the model, which corroborates the idea that the measurement result could be determined by the atom positions. The possible origin of decoherence and entropy increase in future models is finally discussed. (shrink)

In this collection of scenarios and episodes, many of which were experienced by the authors in their years as school administrators, you will find an array of provocative examples of social injustice in the classroom, and what you can do to prevent it in your own school community.

Unusual atmospheric phenomena (UAPs) were observed in daylight by multiple observers on board two civil aircraft in widely separated locations. We summarise results of an investigation based on radio communications reporting events in real time to Air Traffic Control (ATC), ATC radar and weather radar recordings, Civil Aviation Authority (CAA) documents, witness interviews and statements, and other sources. We describe attempts to explain the phenomena with the help of expert specialist advisers and professional resources in the fields of meteorology, atmospheric (...) optics, oceanography and geophysics. We are able to show that widespread media stories describing enormous phenomena up to a mile wide and detected by radar were based on speculation and misunderstandings. Many news reports were grossly exaggerated and inaccurate. However, we are unable to conclusively identify the UAPs observed. It proves possible to eliminate a number of theories with a fairly high level of confidence, leaving us with two types of phenomena—a rare atmospheric-optical effect or an earthquake precursor—both of which have the potential to explain at least some, although not all, features of the reports. We highlight certain features that appear to leave open the possibility of unusual physical processes. Keywords: UAP—atmospheric optics—anomaly—mirage—earthquake lights—EQL. (shrink)

The rise of big digital data is changing the framework within which linguists, sociologists, anthropologists, and other researchers are working. Semiotics is not spared by this paradigm shift. A data-driven computational semiotics is the study with an intensive use of computational methods of patterns in human-created contents related to semiotic phenomena. One of the most promising frameworks in this research program is the Semantic Vector Space (SVS) models and their methods. The objective of this article is to contribute to the (...) exploration of the SVS for a computational semiotics by showing what types of semiotic analysis can be accomplished within this framework. The study is applied to a unique body of digitized artworks. We conducted three short experiments in which we explore three types of semiotic analysis: paradigmatic analysis, componential analysis, and topic modelling analysis. The results reported show that the SVS constitutes a powerful framework within which various types of semiotic analysis can be carried out. (shrink)

Drug exceptional access programs (DEAPs) exist across Canada to address gaps in access to pharmaceuticals. These programs circumvent standard procedures, raising epistemic, economic, social and political issues. This commentary provides insights into these issues by revealing the context and procedures on which these programs depend.

This current volume by a successful consultant to leading organizations and institutions combines two of his recent papers.

O’Donohue et al. sought to derive, from classical ethical theories, the ethical obligation of psychologists to assist “enhanced interrogations and torture” in national defense scenarios under strict EIT criteria. They asked the American Psychological Association to adopt an ethics code obligating psychologists to assist such EIT and to uphold the reputation of EIT psychologists. We contest the authors’ ethical analyses as supports for psychologists’ forays into torture interrogation when the EIT criteria obtain. We also contend that the authors’ application of (...) these ethical analyses violates the Geneva Conventions, contravenes military doctrine and operations, and undermines psychology as a profession. We conclude that “good” public reputation is not owed to, or expected by, “good” intelligence professionals, and collaborating operational psychologists must share their providence. (shrink)

What is philosophy of science? Numerous manuals, anthologies or essays provide carefully reconstructed vantage points on the discipline that have been gained through expert and piecemeal historical analyses. In this paper, we address the question from a complementary perspective: we target the content of one major journal of the field—Philosophy of Science—and apply unsupervised text-mining methods to its complete corpus, from its start in 1934 until 2015. By running topic-modeling algorithms over the full-text corpus, we identified 126 key research topics (...) that span across 82 years. We also tracked their evolution and fluctuating significance over time in the journal articles. Our results concur with and document known and lesser-known episodes of the philosophy of science, including the rise and fall of logic and language-related topics, the relative stability of a metaphysical and ontological questioning (space and time, causation, natural kinds, realism), the significance of epistemological issues about the nature of scientific knowledge as well as the rise of a recent philosophy of biology and other trends. These analyses exemplify how computational text-mining methods can be used to provide an empirical large-scale and data-driven perspective on the history of philosophy of science that is complementary to other current historical approaches. (shrink)

As a continuation of the work of the third author in [5], we make further observations on the features of Galois cohomology in the general model theoretic context. We make explicit the connection between forms of definable groups and first cohomology sets with coefficients in a suitable automorphism group. We then use a method of twisting cohomology (inspired by Serre’s algebraic twisting) to describe arbitrary fibres in cohomology sequences—yielding a useful “finiteness” result on cohomology sets.Applied to the special case of (...) differential fields and Kolchin’s constrained cohomology, we complete results from [3] by proving that the first constrained cohomology set of a differential algebraic group over a bounded, differentially large, field is countable. (shrink)

This collection of essays, originally published in 1970 by Random House, gathers together some of the best initial responses to the problems raised by Edmund Gettier's celebrated critique of the traditional analysis of knowledge. Designed for upper-level courses and seminars in undergraduate philosophy programs and is intended as an introduction to epistemology from the analytic point of view.

Everyone's favorite houseguest who never left, Leon Black (played by award-winning comedian JB Smoove on HBO's Curb Your Enthusiasm) drops his wisdom and good-bad advice for the masses. Learn the secrets Larry David has gleaned from the Falstaff of television."--Amazon.

Running marathons is an increasingly popular activity with an ever-increasing number of events and participants. Many participants declare that they pursue a variety of goals by running, namely, the maintenance of good health, the development of strength and improvement of fitness, the management of emotions, and the achievement of resilience and psychological wellbeing. The research has examined marathon running, like many other sports, and has studied various factors that reduce athletic performance, such as the experience of anxiety, and that enhance (...) such performance, such as an increase in general wellbeing. This article reports the results of a study on the experience of competitive anxiety among 238 male marathon runners who participated in Seville’s 26th Marathon race on February 23, 2020, and investigates the relationship between anxiety and key dimensions of wellbeing as measured by the Spanish-adapted 20-item PWB Scale. We hypothesized that participating athletes who rated high on the dimensions of PWB would experience lower levels of competitive anxiety with respect to this race. We also proposed that PWB would function as a mediating factor with respect to the experience of anxiety. The results show, as hypothesized, that marathon running enhances wellbeing and reduces anxiety. The data showed significant negative correlations between four of five wellbeing dimensions and the three types of anxiety measured, namely, somatic anxiety, worry, and concentration-impairing anxiety. Other findings supported our hypothesis that wellbeing, as measured, functions as a mediating factor for the moderation of competitive anxiety. Generalization of these findings is limited by the fact that the low number of female participants recruited did not permit valid statistical analyses in this respect. It is known that both anxiety and wellbeing are subjects to variation by gender. The future inclusion of male and female subjects in equivalent studies will undoubtedly add valuable information concerning the dynamics of anxiety and wellbeing. The implications of these findings and the limitations of the study will be discussed. (shrink)

Although death by neurologic criteria is legally recognized throughout the United States, state laws and clinical practice vary concerning three key issues: the medical standards used to determine death by neurologic criteria, management of family objections before determination of death by neurologic criteria, and management of religious objections to declaration of death by neurologic criteria. The American Academy of Neurology and other medical stakeholder organizations involved in the determination of death by neurologic criteria have undertaken concerted action to address variation (...) in clinical practice in order to ensure the integrity of brain death determination. To complement this effort, state policymakers must revise legislation on the use of neurologic criteria to declare death. We review the legal history and current laws regarding neurologic criteria to declare death and offer proposed revisions to the Uniform Determination of Death Act and the rationale for these recommendations. (shrink)

BackgroundThe increased risk of developing attention-deficit hyperactivity disorder (ADHD) in extremely preterm infants is well-documented. Better understanding of perinatal risk factors, particularly those that are modifiable, can inform prevention efforts.MethodsWe examined data from the Extremely Low Gestational Age Newborns (ELGAN) Study. Participants were screened for ADHD at age 10 with the Child Symptom Inventory-4 (N = 734) and assessed at age 15 with a structured diagnostic interview (MINI-KID) to evaluate for the diagnosis of ADHD (N = 575). We studied associations (...) of pre-pregnancy maternal body mass index (BMI), pregestational and/or gestational diabetes, maternal smoking during pregnancy (MSDP), and hypertensive disorders of pregnancy (HDP) with 10-year and 15-year ADHD outcomes. Relative risks were calculated using Poisson regression models with robust error variance, adjusted for maternal age, maternal educational status, use of food stamps, public insurance status, marital status at birth, and family history of ADHD. We defined ADHD as a positive screen on the CSI-4 at age 10 and/or meeting DSM-5 criteria at age 15 on the MINI-KID. We evaluated the robustness of the associations to broadening or restricting the definition of ADHD. We limited the analysis to individuals with IQ ≥ 70 to decrease confounding by cognitive functioning. We evaluated interactions between maternal BMI and diabetes status. We assessed for mediation of risk increase by alterations in inflammatory or neurotrophic protein levels in the first week of life.ResultsElevated maternal BMI and maternal diabetes were each associated with a 55–65% increase in risk of ADHD, with evidence of both additive and multiplicative interactions between the two exposures. MSDP and HDP were not associated with the risk of ADHD outcomes. There was some evidence for association of ADHD outcomes with high levels of inflammatory proteins or moderate levels of neurotrophic proteins, but there was no evidence that these mediated the risk associated with maternal BMI or diabetes.ConclusionContrary to previous population-based studies, MSDP and HDP did not predict ADHD outcomes in this extremely preterm cohort, but elevated maternal pre-pregnancy BMI, maternal diabetes, and perinatal inflammatory markers were associated with increased risk of ADHD at age 10 and/or 15, with positive interaction between pre-pregnancy BMI and maternal diabetes. (shrink)

Taiwan was affected by an outbreak of severe acute respiratory syndrome (SARS) in early 2003. A questionnaire survey was conducted to determine (1) the perceptions of risk of SARS infection in nurses; (2) the proportion of nurses considering leaving their job; and (3) work as well as non-work factors related to nurses' consideration of leaving their job because of the SARS outbreak. Nearly three quarters (71.9%) of the participants believed they were 'at great risk of exposure to SARS', 49.9% felt'an (...) increase in workload', and 32.4% thought that people avoided them because of their job; 7.6% of the nurses not only considered that they should not care for SARS patients but were looking for another job or considering resignation. The main predictors of nurses' consideration of leaving their job were shorter tenure, increased work stress, perceived risk of fatality from SARS, and affected social relationships. The findings are important in view of potential impending threats of pandemics such as avian influenza. (shrink)

Jean-Jacques Rousseau's ideas about society, culture, and government are pivotal in the history of political thought. His works are as controversial as they are relevant today. This volume brings together three of Rousseau's most important political writings -- The Social Contract and The First Discourse (Discourse on the Sciences and Arts) and The Second Discourse (Discourse on the Origin and Foundations of Inequality) -- and presents essays by major scholars that shed light on the dimensions and implications of these (...) texts. Susan Dunn's introductory essay underlines the unity of Rousseau's political thought and explains why his ideas influenced Jacobin revolutionaries in France but repelled American revolutionaries across the ocean. Gita May's essay discusses Rousseau as cultural critic. Robert N. Bellah explores Rousseau's attempt to resolve the tension between the individual's desire for freedom and the obligations that society imposes. David Bromwich analyzes Rousseau as a psychologist of the human self. And Conor Cruise O'Brien takes on the "noxious, " "deranged" Rousseau, excoriated by Edmund Burke but admired by Robespierre and Thomas Jefferson. Written from different, even opposing perspectives, these lucid essays convey a sense of the vital and contentious debate surrounding Rousseau and his legacy. (shrink)

Chemosensory systems are complex regulatory pathways capable of perceiving external signals and translating them into different cellular behaviors such as motility and development. In the δ-proteobacterium Myxococcus xanthus, chemosensing allows groups of cells to orient themselves and aggregate into specialized multicellular biofilms termed fruiting bodies. M. xanthus contains eight predicted CSS and 21 chemoreceptors. In this work, we systematically deleted genes encoding components of each CSS and chemoreceptors and determined their effects on M. xanthus social behaviors. Then, to understand how (...) the 21 chemoreceptors are distributed among the eight CSS, we examined their phylogenetic distribution, genomic organization and subcellular localization. We found that, in vivo, receptors belonging to the same phylogenetic group colocalize and interact with CSS components of the respective phylogenetic group. Finally, we identified a large chemosensory module formed by three interconnected CSS and multiple chemoreceptors and showed that complex behaviors such as cell group motility and biofilm formation require regulatory apparatus composed of multiple interconnected Che-like systems. © 2014 Moine et al. (shrink)

The purpose of the present work is twofold. On the one hand, it attempts to provide a critical exposition of the ethical theory of Jean-Paul Sartre. On the other hand, it strives to explain, and in a limited way to defend, the central thesis of that theory, namely, that freedom is the "highest," or most important, value. ;The study begins with an extensive discussion of Sartre's theory of freedom. Sartre's arguments for the freedom of consciousness are identified and presented, (...) and a number of widespread misunderstandings of Sartre's conception of the nature of freedom are corrected. Specifically, it is argued that, contrary to prevailing opinion, Sartre distinguishes between different senses of freedom, insists that freedom is always limited, and remains substantially consistent, throughout his intellectual career, in his understanding of the nature of freedom. ;The study next takes up Sartre's theory of values. Here the well-known strain of ethical subjectivism in Sartre's thought is presented and criticized, with the main instrument of criticism being a distinction, overlooked by Sartre, between subjectivism as a meta-ethical theory about the status of moral judgments, and subjectivism as an ontological doctrine regarding the existence of moral values. ;The study concludes with an explanation and defense of the theory that freedom is the highest value. Here the presentation of Sartre's ethical theory is brought to completion through a discussion of its neglected objectivist elements, and through a development in regard to ethics of Sartre's general theory of knowledge. It is then shown that the notion of freedom as a value underlies both the subjectivist and the objectivist phases of Sartre's ethical thought, and it is suggested that these two phases can be reconciled in a conception of ethics as a dialectic of invention and discovery. This conception is defended by way of a brief discussion of its advantages over rival ethical theories, which neglect one or the other of the stages of this dialectic. (shrink)

This topically organized, interdisciplinary anthology provides competing perspective on the claim that western culture faces a moral crisis. Using clearly written, accessible essays by well-known authors in philosophy, the social sciences, and the humanities, the book introduces students to a variety of perspectives on the current cultural debate about values that percolates beneath the surface of most of our social and political controversies.

We would like to thank the commentators for their generous comments, valuable insights and helpful suggestions. We begin this response by discussing the selfishness axiom and the importance of the preferences, beliefs, and constraints framework as a way of modeling some of the proximate influences on human behavior. Next, we broaden the discussion to ultimate-level (that is evolutionary) explanations, where we review and clarify gene-culture coevolutionary theory, and then tackle the possibility that evolutionary approaches that exclude culture might be sufficient (...) to explain the data. Finally, we consider various methodological and epistemological concerns expressed by our commentators. (shrink)

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

Encounters with Alphonso Lingis is the first extensive study of this American philosopher who is gaining an international reputation to augment his national one. The distinguished contributors to this volume address most of the central themes found in Lingis's writings—including singularity and otherness, death and eroticism, emotions and rationality, embodiment and the face, excess and the sacred. The book closes with a new essay by Lingis himself.

Sartre's interventions at the Vienna, Berlin, and Helsinki Congresses of the World Peace Council are examined in depth. Neglected and overlooked for over a half-century, it is argued that the themes Sartre elaborated in these speeches were consonant with the political and intellectual projects he had been developing since the mid-1930s. Although Sartre spoke as a Marxist who had allied himself with the Communist Party, his deepest concern was to build international unity in opposition to the escalating threat of nuclear (...) war, and to restore political and economic sovereignty to a Western Europe crushed by dependency on America. Freedom for all the world's peoples, Sartre argued, depended on mutual interdependence between nations, built from the ground up by the popular masses. (shrink)